| Catalog No. | Size | Price (USD) |
| 201229-T10-50 | 50 µL | $147.96 |
| 201229-T10-100 | 100 µL | $251.64 |
| 201229-T10-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Bad Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Bad |
| Immunogen | E. coli-derived Human Bad fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Bad fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BAD Antibody; Anti-BBC2 Antibody; Anti-BBC6 Antibody; Anti-BCL2L8 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human BAD in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Bad Immunohistochemistry(IHC) 24181 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human BAD in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human Bad Immunofluorescence(IF) 24182 |
| Image 2 URL | Source image |
Background Information
| Full Name | BCL2-associated agonist of cell death |
| Description | Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown to possess many non-apoptotic functions closely linked to cancer including regulation of glycolysis, autophagy, cell cycle progression and immune system development. Oral squamous cell carcinoma (OSCC) is a type of cancer with high morbidity and mortality rates worldwide; it also demonstrates chemotherapeutic resistance. Triterpenoid ursolic acid has been shown to exhibit various biological activities and anticancer effects in several preclinical studies. The apoptosis‑associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B‑cell lymphoma 2 (Bcl‑2)‑associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl‑2 and Bcl‑extra large (Bcl‑xL), and increased the expression of BAD and Bcl‑2‑associated X (Bax) protein in CAR cells. |
| Related Pathways |
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