Anti-DCLK1 Antibody, Rabbit Polyclonal sinobiological 11588-T08
$243.00
In stock
SKU
11588-T08
| Catalog No. | Size | Price (USD) |
| 11588-T08-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-DCLK1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human DCLK1 |
| Immunogen | Recombinant Human DCLK1 Protein (Catalog#11588-H20B) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human DCLK1 (rh DCLK1; Catalog#11588-H20B; O15075-1; Met1-Val705). DCLK1 specific IgG was purified by Human DCLK1 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CL1 Antibody; Anti-CLICK1 Antibody; Anti-DCAMKL1 Antibody; Anti-DCDC3A Antibody; Anti-DCLK Antibody; Anti-KIAA0369 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human DCLK1 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human DCLK1 Immunohistochemistry(IHC) 45545 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human DCLK1 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human DCLK1 Immunohistochemistry(IHC) 45546 |
| Image 2 URL | Source image |
Background Information
| Full Name | doublecortin-like kinase 1 |
| Description | DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system. |
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