| Catalog No. | Size | Price (USD) |
| 16490-MM16-50 | 50 µL | $147.96 |
| 16490-MM16-100 | 100 µL | $251.64 |
| 16490-MM16-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-LY75/CD205 Antibody, Mouse Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human LY75/CD205 |
| Immunogen | Recombinant Human LY75 / DEC-205 / CD205 Protein (Catalog#16490-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human LY75 / DEC-205 / CD205 (rh LY75 / DEC-205 / CD205; Catalog#16490-H08H; NP_002340.2;Ala32-Gly1664). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #16 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD205 Antibody; Anti-CLEC13B Antibody; Anti-DEC-205 Antibody; Anti-GP200-MR6 Antibody; Anti-LY-75 Antibody
Background Information
| Full Name | lymphocyte antigen 75 |
| Description | LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways implicated in cell proliferation and metabolism, while pathways associated with cell signaling and adhesion, complement activation, and immune response were mostly suppressed. Moreover, LY75 suppression had an opposite effect on EOC cell lines with the epithelial phenotype (A2780s and OV2008), by directing epithelial-to-mesenchymal transition (EMT) associated with reduced capacity for in vivo EOC cell colonization, as similar/identical signaling pathways were reversely regulated, when compared to mesenchymal LY75 knockdown EOC cells. Diseases associated with LY75 include Pneumonic Plague and Adenoiditis. |
