| Catalog No. | Size | Price (USD) |
| 10189-RP02-50 | 50 µL | $147.96 |
| 10189-RP02-100 | 100 µL | $251.64 |
| 10189-RP02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Decorin Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Decorin |
| Immunogen | Recombinant Human Decorin protein (Catalog#10189-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human Decorin (rh Decorin; Catalog#10189-H08H; NP_001911.1; Met 1-Lys 359). Decorin specific IgG was purified by human Decorin affinity chromatography . |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CSCD Antibody; Anti-DSPG2 Antibody; Anti-PG40 Antibody; Anti-PGII Antibody; Anti-PGS2 Antibody; Anti-SLRR1B Antibody
Background Information
| Full Name | decorin |
| Description | Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles. |
| References |
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