| Catalog No. | Size | Price (USD) |
| 10809-RP01-100 | 100 µL | $147.96 |
| 10809-RP01-200 | 200 µL | $251.64 |
| 10809-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-Desmocollin 2/DSC2 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Desmocollin 2/DSC2 |
| Immunogen | Recombinant Human DSC2 protein (Catalog#10809-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human DSC2 (rh DSC2; Catalog#10809-H08H; Q02487-1; Met 1-Arg 684). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ARVD11 Antibody; Anti-CDHF2 Antibody; Anti-DG2 Antibody; Anti-DGII/III Antibody; Anti-DSC3 Antibody
Background Information
| Full Name | desmocollin 2 |
| Description | DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in DSC2 are associated with arrhythmogenic right ventricular dysplasia-11. DSC2 is Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms. |
| References |
|
