| Catalog No. | Size | Price (USD) |
| 100950-T10-50 | 50 µL | $147.96 |
| 100950-T10-100 | 100 µL | $251.64 |
| 100950-T10-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Dppa2 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Dppa2 |
| Immunogen | A synthetic peptide corresponding to the center region of the Human Dppa2 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human Dppa2, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CT100 Antibody; Anti-DPPA2 Antibody; Anti-ECAT15-2 Antibody; Anti-PESCRG1 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human DPPA2 in human brain with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human Dppa2 Immunohistochemistry(IHC) 18381 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human DPPA2 in human brain with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| Image 2 Alt Text | Human Dppa2 Immunofluorescence(IF) 18382 |
| Image 2 URL | Source image |
Background Information
| Description | The assembly of the spherical nucleus depends on a critical balance of microtubule dynamics, which is regulated by the chromatin-binding protein Developmental pluripotency-associated 2 (Dppa2). Whereas microtubules normally promote sperm pronuclear expansion, in Dppa2-depleted Xenopus egg extracts excess microtubules cause pronuclear assembly defects, leading to abnormal morphology and disorganized DNA replication. Dppa2 inhibits microtubule polymerization in vitro, and Dppa2 activity is needed at a precise time and location during nascent pronuclear formation. The developmental pluripotency-associated 2 (Dppa2), which regulates chromatin structures, plays important roles in the maintenance of pluripotency and proliferation of embryonic stem cells. |
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