| Catalog No. | Size | Price (USD) |
| 10204-MM08-P-25 | 25 Tests | $133.30 |
| 10204-MM08-P-100 | 100 Tests | $414.71 |
General Information
| Product name | Anti-E-Cadherin Antibody (PE), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human E-Cadherin |
| Immunogen | Recombinant Human Cadherin-1 / CDH1 / CD324 / E-cadherin protein (Catalog#10204-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cadherin-1 / CDH1 / CD324 / E-cadherin (rh Cadherin-1 / CDH1 / CD324 / E-cadherin; Catalog#10204-H08H; NP_004351.1; Met 1-Ile 707) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Mouse IgG2a Clone #08 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Synonyms: Anti-Arc-1 Antibody; Anti-BCDS1 Antibody; Anti-CD324 Antibody; Anti-CDHE Antibody; Anti-ECAD Antibody; Anti-LCAM Antibody; Anti-UVO Antibody; Anti-uvomorulin Antibody
Image / Experimental Information
| Image 1 Description | Profile of anti-E-cad (CD324) reactivity on MCF-7 cells analyzed by flow cytometry. |
| Image 1 Alt Text | Human E-Cadherin/CDH1/E-cad/CD324 Flow Cytometry (FC) 2601 |
| Image 1 URL | Source image |
| Image 2 Description | Profile of anti-E-cad (CD324) reactivity on MCF-7 cells analyzed by flow cytometry. |
| Image 2 Alt Text | Human E-Cadherin/CDH1/E-cad/CD324 Immunofluorescence(IF) 2942 |
| Image 2 URL | Source image |
Background Information
| Full Name | cadherin 1, type 1, E-cadherin (epithelial) |
| Description | Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas. |
| Research Areas |
|
| Related Pathways |
|
| References |
|
-MM08-FITC-PE-APC-MCF-7.png){kind=link}
