| Catalog No. | Size | Price (USD) |
| 10605-T16-50 | 50 µL | $147.96 |
| 10605-T16-100 | 100 µL | $251.64 |
| 10605-T16-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-EGF Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human EGF |
| Immunogen | Recombinant Human EGF / Epidermal Growth Factor protein (Catalog#10605-HNAE) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human EGF / Epidermal Growth Factor (rh EGF / Epidermal Growth Factor; Catalog#10605-HNAE; NP_001954.2; Asn971-Arg1023). EGF / Epidermal Growth Factor specific IgG was purified by Human EGF / Epidermal Growth Factor affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-HOMG4 Antibody; Anti-URG Antibody
Background Information
| Full Name | epidermal growth factor |
| Description | EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bonds. As a low-molecular-weight polypeptide, EGF was first purified from the mouse submandibular gland, but since then it was found in many human tissues including submandibular gland, parotid gland. It can also be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Salivary EGF, which seems also regulated by dietary inorganic iodine, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. EGF acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation. |
| Related Pathways |
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| References |
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title: A trispecific antibody targeting EGFR/cMET/VEGF-A demonstrates multiple mechanisms of action to inhibit wild-type and mutant NSCLC animal models
authors: Ying Jin; Ping Sun; ...; Mark L. Chiu
journal: Frontiers in Oncology
date: 2025-05-16
doi: 10.3389/fonc.2025.1533059
cited_by_count: 0
techniques: Binding Assay; Blocking Assay; Concentration Assay; Flow Cytometry; Fluorescence; Incubation; Ligand Binding Assay; Negative Control; Positive Control; Software
bioz_score: 93
