| Catalog No. | Size | Price (USD) |
| 10001-RE10-200 | 200 µg | $296.22 |
| 10001-RE10-500 | 500 µg | $444.33 |
General Information
| Product name | EGFR / HER1 / ErbB1 Neutralizing Antibody |
| Validated applications | Neutralization |
| Species reactivity | Reacts with: Human |
| Specificity | Human EGFR Has cross-reactivity in ELISA with Mouse EGFR (Catalog # 51091-M08H) Rat EGFR (Catalog # 80100-R08H) Rhesus EGFR (Catalog # 90317-K08H) |
| Immunogen | Recombinant Human EGFR / HER1 / ErbB1 Protein (Catalog#10001-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; Catalog#10001-H08H; NP_005219; Met1-Ser645) and was produced using recombinant antibody technology. |
| Source | Monoclonal Rabbit IgG Clone #RE10 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0 |
| Conjugate | Unconjugated |
| Endotoxin | < 3 EU/mg |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ERBB Antibody; Anti-ERBB1 Antibody; Anti-ERRP Antibody; Anti-HER1 Antibody; Anti-mENA Antibody; Anti-NISBD2 Antibody; Anti-PIG61 Antibody
Image / Experimental Information
| Image 1 Description | Cell Proliferation Induced by Autocrine EGF was Neutralized by Human EGFR Antibody. Autocrine EGF stimulates proliferation in the human breast cancer MDA-MB-468 cell line. Proliferation elicited by Autocrine EGF is neutralized by increasing concentrations of Human EGFR Monoclonal Antibody (Catalog # 10001-RE10). The IC50 is typically 0.05-0.2 μg/mL. |
| Image 1 Alt Text | Human EGFR/HER1 Blocking/Neutralization (B/N) 5602 |
| Image 1 URL | Source image |
Background Information
| Full Name | epidermal growth factor receptor |
| Description | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. |
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