| Catalog No. | Size | Price (USD) |
| 100372-T32-50 | 50 µL | $147.96 |
| 100372-T32-100 | 100 µL | $251.64 |
| 100372-T32-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-EGFR Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human EGFR |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human EGFR / HER1 / ErbB1 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human EGFR / HER1 / ErbB1, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ERBB Antibody; Anti-ERBB1 Antibody; Anti-ERRP Antibody; Anti-HER1 Antibody; Anti-mENA Antibody; Anti-NISBD2 Antibody; Anti-PIG61 Antibody
Image / Experimental Information
| Image 1 Description | Anti-EGFR rabbit polyclonal antibody at 1:500 dilution Lane A: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:134 kDa Observed band size:200 kDa |
| Image 1 Alt Text | Human EGFR/HER1 Western blot (WB) 6468 |
| Image 1 URL | Source image |
Background Information
| Full Name | epidermal growth factor receptor |
| Description | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. |
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| References |
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title: Computationally designed antibody-drug conjugates self-assembled via affinity ligands.
authors: Nimish Gupta; Aasif Ansari; ...; Shiladitya Sengupta
journal: Nature Biomedical Engineering
date: 2020-03-09
pmid: 31686001
doi: 10.1038/s41551-019-0470-8
cited_by_count: 23
techniques: Concentration Assay; Generated; Incubation; Software
bioz_score: 90
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