| Catalog No. | Size | Price (USD) |
| 100091-T08-50 | 50 µL | $147.96 |
| 100091-T08-100 | 100 µL | $251.64 |
| 100091-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-EphB2 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human EphB2 |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the human EPHB2. |
| Preparation | Produced in rabbits immunized with A synthetic peptide corresponding to the N-terminus of the human EPHB2., and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BDPLT22 Antibody; Anti-CAPB Antibody; Anti-DRT Antibody; Anti-EK5 Antibody; Anti-EPHB2 Antibody; Anti-EPHT3 Antibody; Anti-EPTH3 Antibody; Anti-ERK Antibody; Anti-Hek5 Antibody; Anti-PCBC Antibody; Anti-Tyro5 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human EPHB2 in human skeletal muscle with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human EphB2/Eph Receptor B2 Immunohistochemistry(IHC) 4229 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human EPHB2 in human skeletal muscle with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections). |
| Image 2 Alt Text | Human EphB2/Eph Receptor B2 Immunohistochemistry(IHC) 4230 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human EPHB2 in human skeletal muscle with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections). |
| Image 3 Alt Text | Human EphB2/Eph Receptor B2 Immunohistochemistry(IHC) 17443 |
| Image 3 URL | Source image |
Background Information
| Full Name | EPH receptor B2 |
| Description | Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induces various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB. |
| Related Pathways |
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| References |
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title: Identification of the potential roles of ring finger protein 8 in TP53-mutant breast cancer
authors: Feng Zhao; Peibin Wang; ...; Chaoqian Liu
journal: Oncology Letters
date: 2021-01-01
pmid: 33262834
doi: 10.3892/ol.2020.12303
pmcid: 7693390
cited_by_count: 6
techniques: Bicinchoninic Acid Protein Assay; Expressing; Incubation; Isolation; Lysis; Small Interfering RNA; Western Blot
bioz_score: 90
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