Recombinant Anti-Ephrin-A1 Antibody, Rabbit Monoclonal sinobiological 10882-R114

$1,900.00
In stock
SKU
10882-R114
Catalog No.SizePrice (USD)
10882-R114-11 mL$1,969.87
10882-R114-2020 µL$118.49
10882-R114-5050 µL$177.58
10882-R114-100100 µL$340.51

General Information

Product nameRecombinant Anti-Ephrin-A1 Antibody, Rabbit Monoclonal
Validated applicationsELISA (FAQ Protocol), ELISA(Det) (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman Ephrin-A1 No cross-reactivity in ELISA with Human EphrinA5 / EFNA5 Human EphrinA3 / EFNA3
ImmunogenRecombinant Human EFNA1 protein (Catalog#10882-H08H)
PreparationThis antibody was obtained from a rabbit immunized with purified, recombinant Human EphrinA1 (rh EphrinA1; Catalog#10882-H08H; NP_004419.2; Met 1-Ser 182).
SourceMonoclonal Rabbit IgG Clone #114
PurificationProtein A
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-B61 Antibody; Anti-ECKLG Antibody; Anti-EFL1 Antibody; Anti-EPLG1 Antibody; Anti-GMAN Antibody; Anti-LERK-1 Antibody; Anti-LERK1 Antibody; Anti-TNFAIP4 Antibody

Background Information

Full Nameephrin-A1
DescriptionEPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A1/EFNA1 and its Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. An exception is the EphA4 receptor, which binds both subclasses of ephrins. Ephrin-A1 and one of its receptor EphA2 were expressed in xenograft endothelial cells and also tumor cells and play a role in human cancers, at least in part by influencing tumor neovascularization.
References
  1. Deroanne C, et al. (2003) EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. J Cell Sci. 116(7): 1367-76.
  2. Ojima T, et al. (2006) EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown. Am J Pathol. 168(1): 331-9.
  3. Wu D, et al. (2004) Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma. Gynecol Oncol. 94(2): 312-9.

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