| Catalog No. | Size | Price (USD) |
| 100966-T34-50 | 50 µL | $147.96 |
| 100966-T34-100 | 100 µL | $251.64 |
| 100966-T34-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-EVI1/MECOM Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human EVI1/MECOM |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human MECOM |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human MECOM, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-AML1-EVI-1 Antibody; Anti-EVI1 Antibody; Anti-KMT8E Antibody; Anti-MDS1 Antibody; Anti-MDS1-EVI1 Antibody; Anti-PRDM3 Antibody; Anti-RUSAT2 Antibody
Image / Experimental Information
| Image 1 Description | Anti-MECOM rabbit polyclonal antibody at 1:500 dilution Lane A: A549 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:118 kDa Observed band size:170 kDa (We are unsure as to the identity of these extra bands.) |
| Image 1 Alt Text | Human MECOM Western blot (WB) 14591 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-MECOM rabbit polyclonal antibody at 1:500 dilution Lane A: A549 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:118 kDa Observed band size:170 kDa (We are unsure as to the identity of these extra bands.) |
| Image 2 Alt Text | Human MECOM Immunofluorescence(IF) 14592 |
| Image 2 URL | Source image |
Background Information
| Description | MECOM gene, also known as EVI, encodes a transcriptional regulator involved in hematopoiesis, apoptosis, development and proliferation. In blood system, MECOM is considered an oncogene, but in solid tumors it has both oncogenic and tumor suppressor activities. The MECOM gene encoding a zinc finger protein that functions as a transcription factor, was located on chromosome 3q26, and rearrangements of MECOM often cause its overexpression in acute myeloid leukemia (AML). MECOM encodes a transcription factor that plays an essential role in cell proliferation and maintenance and also in epigenetic regulation.MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. |
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