| Catalog No. | Size | Price (USD) |
| 205036-T08-50 | 50 µL | $147.96 |
| 205036-T08-100 | 100 µL | $251.64 |
| 205036-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-BEX4 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human BEX4 |
| Immunogen | E. coli-derived Human BEX4 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human BEX4 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BEXL1 Antibody; Anti-FLJ10097 Antibody; Anti-NADE3 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human BEX4 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human BEX4 Immunohistochemistry(IHC) 25380 |
| Image 1 URL | Source image |
Background Information
| Description | Human brain-expressed X-linked (BEX) members (BEX1, BEX2, BEX3, BEX4, BEX5) are all located on chromosome Xq22. They are highly conserved genes among different species (including chimp, mouse, rat, dog and human) implying their importance in cellular functions. It has been reported that BEX family members could regulate cell cycle and apoptotic signaling. Among BEX proteins, BEX4 localizes to microtubules and spindle poles, and interacts with α-tubulin (α-TUB) and sirtuin 2 (SIRT2). The overexpression of BEX4 leads to the hyperacetylation of α-TUB by inhibiting SIRT2-mediated deacetylation. BEX4 gene has been identified as a mediator of microtubule hyperacetylation through sirtuin 2 inhibition and is highly overexpressed in human cancers. |
| References |
|
title: Sex differences in hepatocellular carcinoma indicated BEX4 as a potential target to improve efficacy of lenvatinib plus immune checkpoint inhibitors
authors: Lu Liu; Kangkang Yu; ...; Jubo Zhang
journal: Journal of Cancer
date: 2022-01-01
pmid: 36118521
doi: 10.7150/jca.73051
pmcid: 9475366
cited_by_count: 3
techniques: Comparison; Expressing; Immunohistochemistry; Quantitative RT-PCR; Staining
bioz_score: 90
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