| Catalog No. | Size | Price (USD) |
| 13229-RP01-100 | 100 µL | $147.96 |
| 13229-RP01-200 | 200 µL | $251.64 |
| 13229-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-FDPS Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human FDPS |
| Immunogen | Recombinant Human FDPS / Farnesyl Diphosphate Synthase protein (Catalog#13229-H07E) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human FDPS / Farnesyl Diphosphate Synthase (rh FDPS; Catalog#13229-H07E; NP_001129294.1; Met1-Lys353). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FPPS Antibody; Anti-FPS Antibody; Anti-KIAA1293 Antibody; Anti-POROK9 Antibody
Background Information
| Full Name | Farnesyl pyrophosphate synthase |
| Description | Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell. |
| References |
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