| Catalog No. | Size | Price (USD) |
| 10924-R009-50 | 50 µL | $177.58 |
| 10924-R009-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-Follistatin-like 1/FSTL1 Antibody, Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Follistatin-like 1/FSTL1 |
| Immunogen | Recombinant Human FSTL1 protein (Catalog#10924-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human FSTL1 (rh FSTL1; Catalog#10924-H08H; NP_009016.1; Met1-Ile308). |
| Source | Monoclonal Rabbit IgG Clone #009 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FRP Antibody; Anti-FSL1 Antibody; Anti-MIR198 Antibody; Anti-OCC-1 Antibody; Anti-OCC1 Antibody; Anti-tsc36 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Human FSTL1 expression on HeLa cells . The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human FSTL1, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Human FSTL1 Flow Cytometry (FC) 5172 |
| Image 1 URL | Source image |
| Image 2 Description | Flow cytometric analysis of Human FSTL1 expression on HeLa cells . The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human FSTL1, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 2 Alt Text | Human FSTL1 Immunohistochemistry(IHC) 5470 |
| Image 2 URL | Source image |
Background Information
| Full Name | follistatin-like 1 |
| Description | Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling. |
| References |
|
title: Follistatin-like 1 protects endothelial function in the spontaneously hypertensive rat by inhibition of endoplasmic reticulum stress through AMPK-dependent mechanism.
authors: Hanwen Liu; Yanwen Li; ...; Fang Pei
journal: Clinical and experimental hypertension (New York, N.Y. : 1993)
date: 2023-11-16
pmid: 37963199
doi: 10.1080/10641963.2023.2277654
cited_by_count: 5
techniques: Activation Assay; Ex Vivo; Fluorescence; Functional Assay; Incubation; Microscopy; Modification; Phospho-proteomics; Western Blot
bioz_score: 91
