Anti-GGA3 Antibody, Rabbit Polyclonal sinobiological 204424-T36
$243.00
In stock
SKU
204424-T36
| Catalog No. | Size | Price (USD) |
| 204424-T36-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-GGA3 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human GGA3 |
| Immunogen | E. coli-derived Human GGA3 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human GGA3 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-KIAA0154 Antibody
Image / Experimental Information
| Image 1 Description | Anti-GGA3 rabbit polyclonal antibody at 1:500 dilution Lane A: SH-SY5Y Whole Cell Lysate Lane B: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:78 kDa Observed band size:95 kDa |
| Image 1 Alt Text | Human GGA3 Western blot (WB) 44783 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-GGA3 rabbit polyclonal antibody at 1:500 dilution Lane A: SH-SY5Y Whole Cell Lysate Lane B: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:78 kDa Observed band size:95 kDa |
| Image 2 Alt Text | Human GGA3 Immunoprecipitation(IP) 44784 |
| Image 2 URL | Source image |
Background Information
| Description | Golgi-localized γ-ear-containing ARF binding protein 3 (GGA3) is a multidomain clathrin adaptor protein that sorts cargo proteins at the trans-Golgi network (TGN) to the endosome/lysosome pathway. GGA3 interacts directly with the TrkA cytoplasmic tail through an internal DXXLL motif and mediates the functional recycling of TrkA to the plasma membrane. GGA3 regulates the trafficking of the Beta-site APP-cleaving enzyme (BACE1), which is required for production of the Alzheimer's disease (AD)-associated amyloid βpeptide. BACE1 is degraded via the lysosomal pathway and that depletion of GGA3 results in increased BACE1 levels and activity owing to impaired lysosomal trafficking and degradation.GGA3 plays a key role in the trafficking of BACE1 to lysosomes, where it is normally degraded. GGA3 depletion results in BACE1 stabilization both in vitro and in vivo. |
| References |
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