Anti-Glypican 5/GPC5 Antibody, Rabbit Polyclonal sinobiological 10079-T48
$243.00
In stock
SKU
10079-T48
| Catalog No. | Size | Price (USD) |
| 10079-T48-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-Glypican 5/GPC5 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Glypican 5/GPC5 |
| Immunogen | Recombinant Human Glypican 5/GPC5 Protein (Catalog#10079-H08B) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human Glypican 5/GPC5 (rh Glypican 5/GPC5; Catalog#10079-H08B; NP_004457.1; Met1-Thr554). Glypican 5/GPC5 specific IgG was purified by Human Glypican 5/GPC5 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Image / Experimental Information
| Image 1 Description | Anti-Glypican 5/GPC5 rabbit polyclonal antibody at 1:500 dilution Lane A: HepG2 Whole Cell Lysate Lane B: A549 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:65 kDa Observed band size:65 kDa |
| Image 1 Alt Text | Human Glypican 5/GPC5 Western blot (WB) 43869 |
| Image 1 URL | Source image |
Background Information
| Full Name | glypican 5 |
| Description | Glypican-5 (GPC5), is a cell membrane protein that belongs to the glypican family. The glypicans compose a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans that may play a role in the control of cell division and growth regulation. So far, six members (Glypican-1/GPC1, Glypican-2/GPC2, Glypican-3/GPC3, Glypican-4/GPC4, Glypican-5/GPC5, Glypican-6/GPC6) of this family are known in the vertebrates. In the adult, Glypican-5 is primarily expressed in the brain. It is also detected in the fetal brain, lung, and liver. Glypican-5 enhances the intracellular signaling of FGF2 and HGF. It alters the cellular distribution of FGF2. The properties of Glypican-5 make it an attractive target for therapeutic intervention in rhabdomyosarcomas and other tumors that amplify and/or overexpress its gene. Glypican-5 is overexpressed in lymphoma cell lines that had shown amplification. It is a likely target for amplification, and that over-expression of GPC5 may contribute to the development and/or progression of lymphomas and other tumors. |
| References |
|
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
-HD18MY2414-WB.png){kind=link}