Synonyms: Programmed death protein-1 (PD-1) is mainly expressed in activated T cells and belongs to CD28 family. It is a transmembrane protein that binds to its ligand PD-L1, which can significantly inhibit the activation and proliferation of T cells and regulate the expression and secretion of cytokines. At present, PD-1 is mainly used in the research of tumor therapy, and it is also a specific marker of angioimmunoblastic T-cell lymphoma.
Image / Experimental Information
Image 1 Description
Immunochemical staining of human PD-1 in Human tonsil with mouse monoclonal antibody at 150 μL work solution, formalin-fixed paraffin embedded sections. Cellular localization: Cytoplasm, Membrane