| Catalog No. | Size | Price (USD) |
| 10826-RP03-100 | 100 µL | $147.96 |
| 10826-RP03-200 | 200 µL | $251.64 |
| 10826-RP03-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-Progranulin Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Progranulin |
| Immunogen | Recombinant Human GRN protein (Catalog#10826-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human GRN / Granulin (rh GRN; Catalog#10826-H08H; Met 1-Leu 593; NP_002078.1). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CLN11 Antibody; Anti-GEP Antibody; Anti-GP88 Antibody; Anti-PCDGF Antibody; Anti-PEPI Antibody; Anti-PGRN Antibody
Image / Experimental Information
| Image 1 Description | Anti-GRN rabbit polyclonal antibody at 1:500 dilution Lane A: 293T Membrane Lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:64 kDa Observed band size:60 kDa |
| Image 1 Alt Text | Human Progranulin/Granulin Western blot (WB) 17397 |
| Image 1 URL | Source image |
Background Information
| Full Name | Granulin Precursor |
| Description | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat. |
| References |
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