A synthetic peptide corresponding to the N-terminus of the Human H2AFY
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human H2AFY, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Image / Experimental Information
Image 1 Description
Anti-H2AFY rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: HepG2 Whole Cell Lysate Lane C: MCF7 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:40 kDa Observed band size:40 kDa
MACROH2A1 (MacroH2A.1 Histone, also known as H2AFY) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. H2AFY is widely expressed in bone marrow, esophagus, and other tissues. Diseases associated with MACROH2A1 include Liebenberg Syndrome and Medulloblastoma. H2AFY is a potential biomarker associated with disease activity and pharmacodynamic response that may become useful for enabling disease-modifying therapeutics for Huntington's disease (HD). An important paralog of this gene is MACROH2A2.
-HD11JN1525-WB.png){kind=link}