| Catalog No. | Size | Price (USD) |
| 10692-T16-H-100 | 100 µg | $370.28 |
General Information
| Product name | Anti-c-MET/HGFR Antibody (HRP), Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human c-MET/HGFR |
| Immunogen | Recombinant Human c-Met / HGFR protein (Catalog#10692-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human c-Met / HGFR (rh c-Met / HGFR; Catalog#10692-H08H; NP_000236.2; Met1-Thr932). c-Met / HGFR specific IgG was purified by Human c-Met / HGFR affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | HRP |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Protected from prolonged exposure to light. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-AUTS9 Antibody; Anti-c-Met Antibody; Anti-DA11 Antibody; Anti-DFNB97 Antibody; Anti-HGFR Antibody; Anti-RCCP2 Antibody
Background Information
| Full Name | MET proto-oncogene, receptor tyrosine kinase |
| Description | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer. |
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