| Catalog No. | Size | Price (USD) |
| 10598-R023-20 | 20 µL | $118.49 |
| 10598-R023-50 | 50 µL | $177.58 |
| 10598-R023-100 | 100 µL | $370.28 |
General Information
| Product name | Recombinant Anti-IGF1 Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IGF1 Has cross-reactivity in ELISA with Mouse IGF2 No cross-reactivity in ELISA with Human IGF1R Human IGF2 Human IGFBP3 Human IGFBP4 Human IGFBP6 |
| Immunogen | Recombinant Human IGF1 protein (Catalog#10598-HNAE) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human IGF1 (rh IGF1; Catalog#10598-HNAE; P05019-1; Gly49-Ala118). |
| Source | Monoclonal Rabbit IgG Clone #023 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-IBP1 Antibody; Anti-IGF Antibody; Anti-IGF-I Antibody; Anti-IGF1A Antibody; Anti-IGFI Antibody; Anti-MGF Antibody
Background Information
| Full Name | insulin-like growth factor 1 (somatomedin C) |
| Description | IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation. |
| Research Areas |
|
| References |
|
title: Blockade of sonic hedgehog signaling decreases viability and induces apoptosis in retinoblastoma cells: The key role of the PI3K/Akt pathway
authors: Zhidu Song; Yuanyuan Du; Ying Tao
journal: Oncology Letters
date: 2017-10-01
pmid: 28943916
pmcid: 5604099
cited_by_count: 3
techniques: Cell Culture; Construct; Expressing; MTT Assay; Staining; Transfection; Western Blot; shRNA
bioz_score: 90
