| Catalog No. | Size | Price (USD) |
| 206145-T08-50 | 50 µL | $147.96 |
| 206145-T08-100 | 100 µL | $251.64 |
| 206145-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-C17orf99 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human C17orf99 |
| Immunogen | E. coli-derived Human C17orf99 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human C17orf99 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-GLPG464 Antibody; Anti-IL-40 Antibody; Anti-IL40 Antibody; Anti-UNQ464 Antibody; Anti-UNQ464/PRO809 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human C17orf99 in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human C17orf99 Immunohistochemistry(IHC) 25959 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human C17orf99 in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human C17orf99 Immunohistochemistry(IHC) 25960 |
| Image 2 URL | Source image |
Background Information
| Description | C17orf99 (Chromosome 17 Open Reading Frame 99) is located on human chromosome 17q25.3. The C17orf99 protein is biasedly expressed in bone marrow and lymph node. Structurally, the encoded protein is reported to be 27160 Da in mass. The C17orf99 (also known as IL-40; UNQ464) gene is conserved in chimpanzee, dog, mouse, and rat. 91 organisms have orthologs with human gene C17orf99. C17orf99 is a probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. C17orf99 is involved in lymphocyte B cell development and immunoglobulin/IgA production. C17orf99 is associated with some diseases, such as Amelogenesis Imperfecta, Type Ie. An important paralog of this gene is FCRL5. C17orf99 encodes a novel B cell-associated cytokine that plays an important role in humoral immune responses and may also play a role in B cell development. Importantly, IL-40 is also expressed by human activated B cells and by several human B cell lymphomas. IL-40 may play a role in the pathogenesis of certain human diseases. |
| References |
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title: Serum IL-40 is elevated in systemic sclerosis and is linked to disease activity, gastrointestinal involvement, immune regulation and fibrotic processes.
authors: Adéla Navrátilová; Sabína Oreská; ...; Michal Tomčík
journal: Arthritis research & therapy
date: 2025-06-03
pmid: 40457473
doi: 10.1186/s13075-025-03570-3
cited_by_count: 2
techniques: Immunohistochemistry; Incubation
bioz_score: 93
title: IL-40: A New B Cell-Associated Cytokine Up-Regulated in Rheumatoid Arthritis Decreases Following the Rituximab Therapy and Correlates With Disease Activity, Autoantibodies, and NETosis
authors: Adela Navrátilová; Lucie Andrés Cerezo; ...; Ladislav Šenolt
journal: Frontiers in Immunology
date: 2021-10-21
doi: 10.3389/fimmu.2021.745523
pmcid: 8566875
cited_by_count: 11
techniques: Immunofluorescence; Incubation
bioz_score: 90
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