| Catalog No. | Size | Price (USD) |
| 10945-MM02-50 | 50 µL | $147.96 |
| 10945-MM02-100 | 100 µL | $251.64 |
| 10945-MM02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IL-10RB/IL-10R beta Antibody, Mouse Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-10RB/IL-10R beta No cross-reactivity in ELISA with Human IFNGR1 / CD119. |
| Immunogen | Recombinant Human IL10RB protein (Catalog#10945-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL10RB extracellular domain (rh IL10RB; Catalog#10945-H08H; NP_000619.3; Met 1-Ser 220). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #7E2D8 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS with 0.02% Tween 80, pH 7.0 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CDW210B Antibody; Anti-CRF2-4 Antibody; Anti-CRFB4 Antibody; Anti-D21S58 Antibody; Anti-D21S66 Antibody; Anti-IBD25 Antibody; Anti-IL-10R2 Antibody; Anti-IL-10RB Antibody
Background Information
| Full Name | interleukin 10 receptor, beta |
| Description | Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins is required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn's disease and ulcerative colitis phenotypes. Crohn's disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. |
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