Recombinant Human IL17RC protein (Catalog#11747-H08B)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL17RC (rh IL17RC; Catalog#11747-H08B; NP_116121.2; Met 1-Ala 454). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
IL17RC (Interleukin 17 Receptor C) is a Protein Coding gene. This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). IL17RC is widely expressed in the prostate, skin, and other tissues. The hypomethylation within the IL17RC gene promoter in peripheral blood is not suitable for use as a clinical biomarker of AMD. This study highlights the need for considerable replication of epigenetic association studies before clinical application. methylation of IL17RC could play as a marker in choroidal neovascularization (CNV) and degeneration of retinal pigment epithelium (RPE) cells in vitro. Diseases associated with IL17RC include Candidiasis, Familial, 9, and Chronic Mucocutaneous Candidiasis.
Related Pathways
IL17 signaling pathway
References
Allen W, et al. (2010) IL-17RC: A partner in IL-17 signaling and beyond. Semin Immunopathol. 32(1): 33-42.
You ZB, et al. (2007) Differential Expression of IL-17RC Isoforms in Androgen-Dependent and Androgen-Independent Prostate Cancers1. Neoplasia. 9(6): 464-70.
Zrioual S, et al. (2008) IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J Immunol. 180(1): 655-63.
Kuestner RE, et al. (2010) Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F. J Immunol.179(8): 5462-73.