| Catalog No. | Size | Price (USD) |
| 10607-RP01-100 | 100 µL | $147.96 |
| 10607-RP01-200 | 200 µL | $251.64 |
| 10607-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-IL-36 alpha/IL-1F6 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-36 alpha/IL-1F6 |
| Immunogen | Recombinant Human IL1F6 / IL36A protein (Catalog#10607-HNAE) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human IL1F6 / IL36A (rh IL1F6 / IL36A; Catalog#10607-HNAE; Q9UHA7; Met 1-Phe 158). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FIL1 Antibody; Anti-FIL1(EPSILON) Antibody; Anti-FIL1E Antibody; Anti-IL-1F6 Antibody; Anti-IL1(EPSILON) Antibody; Anti-IL1E Antibody; Anti-IL1F6 Antibody; Anti-MGC129552 Antibody; Anti-MGC129553 Antibody
Background Information
| Full Name | interleukin 36, alpha |
| Description | Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP. |
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