| Catalog No. | Size | Price (USD) |
| 10125-RP01-100 | 100 µL | $147.96 |
| 10125-RP01-200 | 200 µL | $251.64 |
| 10125-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-IL-36RN/IL-1F5 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-36RN/IL-1F5 |
| Immunogen | Recombinant Human IL-1F5 Protein (Catalog#10125-HNAE) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human IL-1F5 (rh IL-1F5; Catalog#10125-HNAE; Q9UBH0; Met1-Asp155). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FIL1 Antibody; Anti-FIL1(DELTA) Antibody; Anti-FIL1D Antibody; Anti-IL-1F5 Antibody; Anti-IL-36Ra Antibody; Anti-IL1F5 Antibody; Anti-IL1HY1 Antibody; Anti-IL1L1 Antibody; Anti-IL1RP3 Antibody; Anti-IL36RA Antibody; Anti-MGC29840 Antibody; Anti-PSORP Antibody; Anti-PSORS14 Antibody; Anti-UNQ1896/PRO4342 Antibody
Background Information
| Full Name | interleukin 36 receptor antagonist |
| Description | Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist, and interleukin-1 receptor type I (IL-1R1), which is present in epithelial barriers and takes part in the local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8, as the effects were not observed in SIGIRR-/- mice. In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain. |
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