| Catalog No. | Size | Price (USD) |
| 10402-R001-200 | 200 µg | $296.22 |
| 10402-R001-500 | 500 µg | $444.33 |
General Information
| Product name | IL-4R / CD124 Neutralizing Antibody |
| Validated applications | Neutralization |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-4R / CD124 (Can block the binding between IL4 and IL4R) No cross-reactivity in ELISA with Mouse IL4R (Catalog # 51180-M08H) Rat IL4R (Catalog # 80198-R08H) |
| Immunogen | Recombinant Human IL-4R / CD124 Protein (Catalog#10402-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-4R / CD124 (rh IL-4R / CD124; Catalog#10402-H08H; NP_000409.1; Met1-His232) and was produced using recombinant antibody technology. |
| Source | Monoclonal Rabbit IgG Clone #R001 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0 |
| Conjugate | Unconjugated |
| Endotoxin | < 3 EU/mg |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-582J2.1 Antibody; Anti-CD124 Antibody; Anti-IL-4RA Antibody; Anti-IL4RA Antibody
Image / Experimental Information
| Image 1 Description | Cell Proliferation Induced by IL4 was Neutralized by Human IL4R Antibody. Recombinant Human IL4 stimulates proliferation in the TF-1 human erythroleukemia cell line. Proliferation elicited by Recombinant Human IL4 (0.2 ng/mL) is neutralized by increasing concentrations of Human IL4R Monoclonal Antibody (Catalog # 10402-R001). The IC50 is typically 5-10 ng/mL. |
| Image 1 Alt Text | Human IL-4R/CD124 Blocking/Neutralization (B/N) 5600 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 4 receptor |
| Description | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. CD124, also known as the interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to a soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. |
| Related Pathways |
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| References |
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title: Interleukin-4 receptor antibody and application thereof
authors: Deyong Song; Chuangchuang Dong; Jing Han
date: 2025-06-24
cited_by_count: 0
techniques: Activity Assay; Binding Assay; Blocking Assay; Comparison; Concentration Assay; Control; Enzyme-linked Immunosorbent Assay; Incubation; Protein Binding
bioz_score: 93
