| Catalog No. | Size | Price (USD) |
| 10402-R209-P-25 | 25 Tests | $133.30 |
| 10402-R209-P-100 | 100 Tests | $414.71 |
General Information
| Product name | Recombinant Anti-IL-4R Antibody (PE), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-4R |
| Immunogen | Recombinant Human IL-4R/CD124 Protein (Catalog#10402-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-4R / CD124 (rh IL-4R / CD124; Catalog#10402-H08H; NP_000409.1; Met1-His232) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Rabbit IgG Clone #209 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-582J2.1 Antibody; Anti-CD124 Antibody; Anti-IL-4RA Antibody; Anti-IL4RA Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of human IL4R(CD124) expression on human whole blood lymphocytes. Cells were stained with PE-conjugated anti-Human IL4R(CD124) and APC-conjugated anti-Human CD19(BD Pharmingen™). The fluorescence histogram were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Image 1 Alt Text | Human IL-4R/CD124 Flow Cytometry (FC) 5125 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 4 receptor |
| Description | The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. CD124, also known as the interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to a soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. |
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| References |
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