| Catalog No. | Size | Price (USD) |
| 11648-MM03-P-25 | 25 Tests | $103.68 |
| 11648-MM03-P-100 | 100 Tests | $133.30 |
General Information
| Product name | Anti-Jagged 1/JAG1 Antibody (PE), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Jagged 1/JAG1 |
| Immunogen | Recombinant Human JAG1 / Jagged 1 protein (Catalog#11648-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAG1 / Jagged 1 (rh JAG1 / Jagged 1; Catalog#11648-H08H; NP_000205.1; Met1-Ser1046) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Mouse IgG2a Clone #03 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-AGS Antibody; Anti-AGS1 Antibody; Anti-AHD Antibody; Anti-AWS Antibody; Anti-CD339 Antibody; Anti-CMT2HH Antibody; Anti-DCHE Antibody; Anti-HJ1 Antibody; Anti-JAGL1 Antibody
Image / Experimental Information
| Image 1 Description | Profile of anti-JAG1(CD339) reactivity on HepG2 cells analyzed by flow cytometry. |
| Image 1 Alt Text | Human Jagged 1/JAG1/CD339 Flow Cytometry (FC) 2572 |
| Image 1 URL | Source image |
Background Information
| Full Name | jagged 1 |
| Description | Protein Jagged 1, also known as JAG1, JAGL1, and CD339, is a single-pass type I membrane protein that contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expression of JAG1/Jagged 1 is up-regulated in cervical squamous cell carcinoma. JAG1/Jagged 1 is also expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. JAG1/Jagged 1 is a ligand for multiple Notch receptors. It is involved in the mediation of Notch signaling. JAG1/Jagged 1 may be involved in cell-fate decisions during hematopoiesis. JAG1/Jagged 1 seems to be involved in the early and late stages of mammalian cardiovascular development. It inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1/Jagged 1 are the cause of Alagille syndrome type 1 (ALGS1). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. Defects in JAG1/Jagged 1 are also a cause of tetralogy of Fallot (TOF). TOF is a congenital heart anomaly that consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left), and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. |
| Research Areas |
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| References |
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title: TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion
authors: Tala O. Khatib; Brian A. Pedro; ...; Adam I. Marcus
journal: Cell Reports
date: 2025-03-12
pmid: 39955775
doi: 10.1016/j.celrep.2025.115315
pmcid: 11951108
cited_by_count: 8
techniques: Bicinchoninic Acid Protein Assay; RNA Sequencing; Recombinant; Reverse Transcription; Staining
bioz_score: 93
title: Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes
authors: Muhammad Rizwan; Ana Fokina; ...; Molly S. Shoichet
journal: Advanced Functional Materials
date: 2020-10-23
doi: 10.1002/adfm.202006116
cited_by_count: 24
techniques: Isolation; Mass Spectrometry; Modification; Purification; Recombinant; SYBR Green Assay
bioz_score: 93
title: Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning
authors: Emily R. Summerbell; Janna K. Mouw; ...; Adam I. Marcus
journal: Science Advances
date: 2020-07-01
pmid: 32832657
doi: 10.1126/sciadv.aaz6197
pmcid: 7439406
cited_by_count: 46
bioz_score: 93
title: The impact of parathyroid hormone treated mesenchymal stem cells on ex-vivo expansion of cord blood hematopoietic stem cells
authors: Mohammadhosein Esmaeili; Vahid Niazi; ...; Kamran Atarodi
journal: Gene Reports
date: 2019-12-01
doi: 10.1016/j.genrep.2019.100490
cited_by_count: 8
techniques: Expressing; Flow Cytometry
bioz_score: 93
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