| Catalog No. | Size | Price (USD) |
| 203716-T08-50 | 50 µL | $147.96 |
| 203716-T08-100 | 100 µL | $251.64 |
| 203716-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-C7orf49 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human C7orf49 |
| Immunogen | E. coli-derived Human C7orf49/CYREN fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human C7orf49/CYREN fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-C7orf49 Antibody; Anti-CYREN-1 Antibody; Anti-CYREN-2 Antibody; Anti-FLJ22450 Antibody; Anti-FLJ27285 Antibody; Anti-MGC5242 Antibody; Anti-MRI Antibody; Anti-MRI-2 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human C7orf49 in human esophagus with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human C7orf49 Immunohistochemistry(IHC) 22350 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human C7orf49 in human esophagus with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human C7orf49 Immunohistochemistry(IHC) 22351 |
| Image 2 URL | Source image |
Background Information
| Full Name | chromosome 7 open reading frame 49 |
| Description | CYREN (Cell cYcle REgulator of NHEJ) was originally identified as a potential modulator of retroviral infection. The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). MRI is intrinsically disordered and interacts with many DNA damage response (DDR) proteins, including the kinases ataxia telangiectasia mutated (ATM) and DNA-PKcs and the classical non-homologous end joining (cNHEJ) factors Ku70, Ku80, XRCC4, XLF, PAXX, and XRCC4. MRI forms large multimeric complexes that depend on its N and C termini and localizes to DNA double-strand breaks (DSBs), where it promotes the retention of DDR factors. Mice deficient in MRI and XLF exhibit embryonic lethality at a stage similar to those deficient in the core cNHEJ factors XRCC4 or DNA ligase IV. Moreover, MRI is required for cNHEJ-mediated DSB repair in XLF-deficient lymphocytes. MRI is an adaptor that, through multivalent interactions, increases the avidity of DDR factors to DSB-associated chromatin to promote cNHEJ. |
| References |
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