Recombinant Human LAIR2 (CD306) Protein (Catalog#10868-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human LAIR2 (CD306) (rh LAIR2 (CD306); Catalog#10868-H08H; NP_002279.2; Met1-Pro152).
Source
Monoclonal Rabbit IgG Clone #001
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
leukocyte associated immunoglobulin like receptor 2
Description
Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD306, is a 131 amino acid protein containing one Ig-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.
Research Areas
ITIM/ITAM Immunoreceptors and Related Molecules
References
Meyaard, L. et al.,1997, Immunity.7:283-290.
Meyaard, L. et al.,1999, J. Immunol. 162:5800-5804.
Meyaard, L. et al., 2001, J. Exp. Med. 194 (1): 107-112.