| Catalog No. | Size | Price (USD) |
| 10527-RP01-100 | 100 µL | $147.96 |
| 10527-RP01-200 | 200 µL | $251.64 |
| 10527-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-LAMP3/CD208 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human LAMP3/CD208 |
| Immunogen | Recombinant Human LAMP3 protein (Catalog#10527-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human CD208 / LAMP3 (rh LAMP3; Catalog#10527-H08H; NP_055213.2; Lys 28-Thr 381). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD208 Antibody; Anti-DC LAMP Antibody; Anti-DC-LAMP Antibody; Anti-DCLAMP Antibody; Anti-LAMP Antibody; Anti-LAMP-3 Antibody; Anti-TSC403 Antibody
Background Information
| Full Name | lysosomal associated membrane protein 3 |
| Description | Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as a marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in the activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces. |
| References |
|
title: Lit-LAMP-DNA-vaccine for shrimp allergy prevents anaphylactic symptoms in a murine model.
authors: Kaori Kubo; Shinobu Takeda; ...; Hidehiko Fukahori
journal: International Immunopharmacology
date: 2022-12-02
pmid: 36334369
doi: 10.1016/j.intimp.2022.109394
cited_by_count: 10
techniques: Blocking Assay; DC Protein Assay; Expressing; Generated; Molecular Weight; Protease Inhibitor; Protein Concentration; Western Blot
bioz_score: 90
