Anti-CACNB4 Antibody, Rabbit Polyclonal sinobiological 205294-T08

$143.00
In stock
SKU
205294-T08
Catalog No.SizePrice (USD)
205294-T08-5050 µL$147.96
205294-T08-100100 µL$251.64
205294-T08-200200 µL$355.32

General Information

Product nameAnti-CACNB4 Antibody, Rabbit Polyclonal
Validated applicationsIHC-P (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CACNB4
ImmunogenE. coli-derived Human CACNB4 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human CACNB4 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-CAB4 Antibody; Anti-CACNLB4 Antibody; Anti-EA5 Antibody; Anti-EIG9 Antibody; Anti-EJM Antibody; Anti-EJM4 Antibody; Anti-EJM6 Antibody

Image / Experimental Information

Image 1 DescriptionImmunochemical staining of human CACNB4 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Image 1 Alt TextHuman CACNB4 Immunohistochemistry(IHC) 25407
Image 1 URLSource image

Background Information

DescriptionThe CACNB4 gene belongs to a family of genes that provide instructions for making calcium channels. These channels, which transport positively charged calcium atoms (calcium ions) into cells, play a key role in a cell's ability to generate and transmit electrical signals. P/Q-type channels are the principal presynaptic calcium channels in brain functioning in neurotransmitter release. They are composed of the pore-forming CaV2.1 α1 subunit and the auxiliary α2δ-2 and β4 subunits. β4 is encoded by CACNB4, and its multiple splice variants serve isoform-specific functions as channel subunits and transcriptional regulators in the nucleus.
References
  1. Coste de Bagneaux P, et al. (2020) A homozygous missense variant in cacnb4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions. PLoS Genet 16 (3): e1008625.

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