| Catalog No. | Size | Price (USD) |
| 11792-RP02-50 | 50 µL | $147.96 |
| 11792-RP02-100 | 100 µL | $251.64 |
| 11792-RP02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-M-CSF/CSF1 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human M-CSF/CSF1 |
| Immunogen | Recombinant Human M-CSF / CSF-1 protein (Catalog#11792-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human M-CSF / CSF-1 (rh M-CSF / CSF-1; Catalog#11792-H08H; P09603-1; Met 1-Asn 190). M-CSF / CSF-1 specific IgG was purified by Human M-CSF / CSF-1 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CSF-1 Antibody; Anti-M-CSF Antibody; Anti-MCSF Antibody; Anti-MGC31930 Antibody; Anti-PG-M-CSF Antibody
Background Information
| Full Name | colony stimulating factor 1 (macrophage) |
| Description | Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression. |
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