Produced in rabbits immunized with purified, recombinant Human MBD3 isoform 2 (O95983-2; Met 1-Val 259). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Background Information
Full Name
methyl-CpG binding domain protein 3
Description
MBD3 (Methyl-CpG Binding Domain Protein 3) is a Protein Coding gene. MBD3 is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. MBD3 is essential for embryonic development and differentiation and to act by suppressing gene expression through the recruitment of co-repressor complexes. MBD3 is also involved in maintaining the demethylated and active state of rRNA genes, and that depletion of MBD3 results in hypermethylation of rRNA promoters.
