| Catalog No. | Size | Price (USD) |
| 111676-R0016-20 | 20 µL | $103.53 |
| 111676-R0016-100 | 100 µL | $296.07 |
General Information
| Product name | Phospho-EGF Receptor (Thr669, Thr693) Antibody, Rabbit MAb |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human Predicted to React with: Species predicted to react based on 100% sequence homology: Mouse, Cynomolgus |
| Specificity | Phospho-EGF Receptor (Thr669), which correspond to Phospho-EGF Receptor (Thr693) of P00533-1 in UniProt. Species predicted to react based on 100% sequence homology: Mouse, Cynomolgus |
| Immunogen | A synthetic peptide corresponding to the residues around (Thr669) of Human EGF Receptor |
| Preparation | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to the residues around (Thr669) of Human EGF Receptor. |
| Source | Monoclonal Rabbit IgG Clone #0016 |
| Purification | Protein A |
| Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ERBB Antibody; Anti-ERBB1 Antibody; Anti-ERRP Antibody; Anti-HER1 Antibody; Anti-mENA Antibody; Anti-NISBD2 Antibody; Anti-PIG61 Antibody
Image / Experimental Information
| Image 1 Description | Western blot analysis of extracts from serum-starved Hela, untreated(line A) or treated with EGF (Cat:10605-HNAE) (100ng/mL, 10min; +)(line B), using Phospho-EGF Receptor (Thr669) rabbit monoclonal Antibody (Cat: 111676-R0016) at 1:2000 dilution (upper) or Anti-EGF Receptor Antibody, Rabbit Polyclonal (Cat: 100372-T32) at 1:1000 dilution (lower). |
| Image 1 Alt Text | Human EGFR Western blot (WB) 43465 |
| Image 1 URL | Source image |
| Image 2 Description | Western blot analysis of extracts from serum-starved Hela, untreated(line A) or treated with EGF (Cat:10605-HNAE) (100ng/mL, 10min; +)(line B), using Phospho-EGF Receptor (Thr669) rabbit monoclonal Antibody (Cat: 111676-R0016) at 1:2000 dilution (upper) or Anti-EGF Receptor Antibody, Rabbit Polyclonal (Cat: 100372-T32) at 1:1000 dilution (lower). |
| Image 2 Alt Text | Human EGFR Western blot (WB) 43466 |
| Image 2 URL | Source image |
Background Information
| Full Name | epidermal growth factor receptor |
| Description | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. |
| Research Areas |
|
| Related Pathways |
|
| Tags |
|
| References |
|
