Anti-CAND1 Antibody, Rabbit Polyclonal sinobiological 100869-T08
$243.00
In stock
SKU
100869-T08
| Catalog No. | Size | Price (USD) |
| 100869-T08-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-CAND1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Mouse, Rat (Species predicted to react based on 100% sequence homology) |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Human CAND1 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human CAND1, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-DKFZp434M1414 Antibody; Anti-KIAA0829 Antibody; Anti-TIP120 Antibody; Anti-TIP120A Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CAND1 in human ovarian cancer with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CAND1 Immunohistochemistry(IHC) 37615 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CAND1 in human ovarian cancer with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human CAND1 Immunohistochemistry(IHC) 37616 |
| Image 2 URL | Source image |
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Background Information
| Full Name | cullin-associated and neddylation-dissociated 1 |
| Description | Cullin-associated NEDD8-dissociated 1 (CAND1) plays a vital role in regulating the activity of Cullin-RING ubiquitin ligases (CRLs), which are frequently dysregulated in cancer. CAND1 expression as a predictor of poor prognosis for HCC patients. CAND1 silencing suppressed HCC cell proliferation by inducing caspase-8/RIP1-dependent apoptosis. That CAND1 could be a new therapeutic target for liver cancer. The miR-33a was decreased in non-small cell lung cancer (NSCLC) tissues compared with the para-carcinoma tissues, whereas its target mRNA of cullin-associated NEDD8-dissociated protein 1 (CAND1) was increased in NSCLC tissues. the miR-33a and CAND1 played an important role in lung cancer proliferation and cell migration. CAND1 inhibits the ubiquitylation of rabphilin-3A and positively regulates AVP secretion. CAND1 is a regulator of hormone or neurotransmitter secretion. The Cullin exchange factor CAND1 is a biochemical target of C60. We also identified CAND1 in an shRNA library screen for EBV lytic reactivation. |
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