| Catalog No. | Size | Price (USD) |
| 11050-RC6-200 | 200 µg | $296.22 |
| 11050-RC6-500 | 500 µg | $444.33 |
General Information
| Product name | NGF / NGFB Neutralizing Antibody |
| Validated applications | Neutralization |
| Species reactivity | Reacts with: Human |
| Specificity | Human Beta-NGF Has cross-reactivity in ELISA with Mouse β-NGF (Catalog # 50385-MNAC) |
| Immunogen | Recombinant Human NGF / NGFB protein (Catalog#11050-HNAC) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human NGF / NGFB (rHuman NGF / NGFB; Catalog#11050-HNAC; NP_002497.2; Ser122-Arg239) and was produced using recombinant antibody technology. |
| Source | Monoclonal Rabbit IgG Clone #RC6 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Endotoxin | Please contact us for more information. |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Beta-NGF Antibody; Anti-HSAN5 Antibody; Anti-NGFB Antibody
Image / Experimental Information
| Image 1 Description | Cell Proliferation Induced by β-NGF was Neutralized by Human β-NGF Antibody. Recombinant Human β-NGF (Catalog #11050-HNAC) stimulates proliferation of TF-1 human erythroleukemic cells. Proliferation elicited by 5 ng/mL of Recombinant Human β-NGF is neutralized by increasing concentrations of Rabbit Anti-Human β-NGF neutralizing Monoclonal Antibody (Catalog # 11050-RC6). The IC50 is typically 17-70 ng/mL. |
| Image 1 Alt Text | Human NGF/NGFB/beta-NGF Blocking/Neutralization (B/N) 5590 |
| Image 1 URL | Source image |
Background Information
| Full Name | nerve growth factor (beta polypeptide) |
| Description | Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF (beta-NGF), was demonstrated to exhibits the growth-stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein that homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. Also, previous studies indicated that NGF may also have an important role in the regulation of the immune system. |
| Related Pathways |
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| References |
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title: YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
authors: Tianyu Shen; Yang Li; ...; Xiaoyue Tan
journal: Biochimica et biophysica acta. Molecular basis of disease
date: 2022-10-18
pmid: 36100154
doi: 10.1016/j.bbadis.2022.166540
cited_by_count: 17
techniques: Cell Culture; Chemotaxis Assay; Co-Culture Assay; Co-Immunoprecipitation Assay; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Isolation; Luciferase; Staining; Transfection; Transwell Assay; Western Blot
bioz_score: 90
