| Catalog No. | Size | Price (USD) |
| 12473-MM11-1 | 1 mL | $1,377.43 |
| 12473-MM11-20 | 20 µL | $88.87 |
| 12473-MM11-50 | 50 µL | $147.96 |
| 12473-MM11-100 | 100 µL | $251.64 |
| 12473-MM11-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-PHPT1 Antibody, Mouse Monoclonal |
| Validated applications | ELISA(Cap) (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human PHPT1 |
| Immunogen | Recombinant Human PHPT1 Protein (Catalog#12473-H07E) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PHPT1 (rh PHPT1; Catalog#12473-H07E; Q9NRX4-1; Ala2-Tyr125). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #11 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-bA216L13.10 Antibody; Anti-CGI-202 Antibody; Anti-DKFZp564M173 Antibody; Anti-HEL-S-132P Antibody; Anti-HSPC141 Antibody; Anti-PHP Antibody; Anti-PHP14 Antibody
Background Information
| Full Name | phosphohistidine phosphatase 1 |
| Description | PHPT1, also known as 14 kDa phosphohistidine phosphatase, phosphohistidine phosphatase 1, protein janus-A homolog, PHP14, is a cytoplasm protein which belongs to the janus family. PHPT1 / PHP14 is expressed abundantly in heart and skeletal muscle. Phosphatases are a diverse group of enzymes that regulate numerous cellular processes. Much of what is known relates to the tyrosine, threonine, and serine phosphatases, whereas the histidine phosphatases have not been studied as much. Protein histidine phosphorylation exists widely in vertebrates, and it plays important roles in signal transduction and other cellular functions. Protein histidine phosphorylation accounts for about 6% of the total protein phosphorylation in eukaryotic cells. The knowledge about eukaryotic PHPT (protein histidine phosphatase) is still very limited. To date, only one vertebrate PHPT has been discovered, and two crystal structures of human PHPT1 have been solved. PHPT1 / PHP14 can dephosphorylate a variety of proteins (e.g. ATP-citrate lyase and the beta-subunit of G proteins). A putative active site has been identified by its electrostatic character, ion binding, and conserved protein residues. |
| References |
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