Anti-VEGF121 Antibody, Rabbit Monoclonal sinobiological 10008-R064

$1,900.00
In stock
SKU
10008-R064
Catalog No.SizePrice (USD)
10008-R064-11 mL$1,969.87
10008-R064-2020 µL$118.49
10008-R064-5050 µL$177.58
10008-R064-100100 µL$340.51

General Information

Product nameAnti-VEGF121 Antibody, Rabbit Monoclonal
Validated applicationsELISA (FAQ Protocol), ELISA(Det) (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman VEGF121/VEGFA Has cross-reactivity in ELISA with Human VEGF165 No cross-reactivity in ELISA with Human VEGFC Human VEGFD
ImmunogenRecombinant Human VEGF121/VEGFA protein (Catalog#10008-HNAB)
PreparationThis antibody was obtained from a rabbit immunized with purified, recombinant Human VEGF121/VEGFA (rh VEGF121/VEGFA; Catalog#10008-HNAB; P15692-9; Met1-Arg147).
SourceMonoclonal Rabbit IgG Clone #064
PurificationProtein A
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-L-VEGF Antibody; Anti-MVCD1 Antibody; Anti-VEGF Antibody; Anti-VEGF-A Antibody; Anti-VPF Antibody

Background Information

Full Namevascular endothelial growth factor A
DescriptionVascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability, thus it was originally referred to as vascular permeability factor.
Research Areas
  • Cancer Drug Targets
Related Pathways
  • VEGF Signaling Pathway
Tags
  • Cancer Immunotherapy
  • Immune Checkpoint
  • Immunotherapy
  • Targeted Therapy
References
  1. Woolard J. et al. (2004) VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res. 64(21): 7822-7835.
  2. Jia SF, et al. (2008) VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. J Exp Ther Oncol. 7(2): 89-97.
  3. Cimpean AM, et al. (2008) Vascular endothelial growth factor A (VEGF A) as individual prognostic factor in invasive breast carcinoma. Rom J Morphol Embryol. 49(3): 303-8.
  4. Hamdollah Zadeh MA, et al. (2008) VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation. 15(7): 605-14.
  5. Eisenach PA, et al. (2010) MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src. J Cell Sci. 123(Pt 23):4182-4193.
  6. Claesson-Welsh L (2010) Gremlin: vexing VEGF receptor agonist. Blood. 116(18):3386-7.

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