| Catalog No. | Size | Price (USD) |
| 10359-R122-P-25 | 25 Tests | $162.92 |
| 10359-R122-P-100 | 100 Tests | $325.84 |
General Information
| Product name | Recombinant Anti-Interferon alpha/beta receptor 2 Antibody (PE), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Interferon alpha/beta receptor 2 |
| Immunogen | Recombinant Human IFNAR2 Protein (Catalog#10359-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human IFNAR2 (rh IFNAR2; Catalog#10359-H08H; NP_997468.1; Met1-Lys243) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Rabbit IgG Clone #122 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 10 μl/Test, 0.1 mg/ml |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-IFN-alpha-REC Antibody; Anti-IFN-R Antibody; Anti-IFN-R-2 Antibody; Anti-IFNABR Antibody; Anti-IFNARB Antibody; Anti-IMD45 Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Human IFNAR2 expression on Jurkat cells. Cells were stained with PE-conjugated anti-Human IFNAR2. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Human IFNAR2 Flow Cytometry (FC) 20432 |
| Image 1 URL | Source image |
Background Information
| Full Name | interferon (alpha, beta and omega) receptor 2 |
| Description | Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNα therapy, IFNAR2 expression at diagnosis was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNα therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2, and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNα2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNβ, it recycles back to the cell surface. |
| References |
|
title: A novel FcγRIIa-TRIM54-STAT2 axis negatively regulates type I interferon signaling and promotes viral susceptibility in human monocytes.
authors: Xiao-Qiu Dai; Shenghao Hua; ...; Fang-Yuan Gong
journal: Journal of virology
date: 2026-05-29
pmid: 42212562
doi: 10.1128/jvi.02106-25
cited_by_count: 0
bioz_score: 94
title: Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation.
authors: Li Li; Jia-Min Dong; ...; Ying Wu
journal: Journal of natural medicines
date: 2023-08-31
pmid: 37488321
doi: 10.1007/s11418-023-01702-0
cited_by_count: 8
techniques: Bicinchoninic Acid Protein Assay; Blocking Assay; Imaging; Incubation; Software; Western Blot
bioz_score: 91
title: Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity.
authors: Yuichi Mitsui; Tatsuya Suzuki; ...; Takashi Satoh
journal: Immunity
date: 2023-08-11
pmid: 37442134
doi: 10.1016/j.immuni.2023.06.013
cited_by_count: 17
techniques: Blocking Assay; Control; Enzyme-linked Immunosorbent Assay; Injection; Labeling; Plasmid Preparation; Polymer; Recombinant; Staining; Variant Assay; Virus
bioz_score: 91
