| Catalog No. | Size | Price (USD) |
| 51065-R208-F-25 | 25 Tests | $133.30 |
| 51065-R208-F-100 | 100 Tests | $414.71 |
General Information
| Product name | Recombinant Anti-IL-17A Antibody (FITC), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse IL-17A |
| Immunogen | Recombinant Mouse IL-17A Protein (Catalog#51065-MNAE) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-17A (rM IL-17A; Catalog#51065-MNAE; Q62386; Thr22-Ala158) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Source | Monoclonal Rabbit IgG Clone #208 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 10 μl/Test, 0.1 mg/ml |
| Conjugate | FITC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-Ctla-8 Antibody; Anti-Ctla8 Antibody; Anti-IL-17 Antibody; Anti-IL-17A Antibody; Anti-Il17 Antibody; Anti-Il17a Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Mouse IL17 expression on EL4 cells.The cells were stimulated for 4-6 hours with PMA and Ionomycin in the presence of GolgiPlug. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with FITC-conjugated anti-Mouse IL17. The dot plots were derived from gated of intact cells. |
| Image 1 Alt Text | Mouse IL17RA Flow Cytometry (FC) 35564 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 17A |
| Description | IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis. |
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