Anti-CASP8/ALPS2B Antibody, Rabbit Polyclonal sinobiological 310195-T46

$243.00
In stock
SKU
310195-T46
Catalog No.SizePrice (USD)
310195-T46-100100 µL$251.64

General Information

Product nameAnti-CASP8/ALPS2B Antibody, Rabbit Polyclonal
Validated applicationsWB (FAQ Protocol), IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol), IP (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CASP8/ALPS2B
ImmunogenE. coli-derived Human CASP8/ALPS2B fragment
PreparationProduced in rabbits immunized with E. coli-derived Human CASP8/ALPS2B fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-ALPS2B Antibody; Anti-CAP4 Antibody; Anti-Casp-8 Antibody; Anti-FLICE Antibody; Anti-MACH Antibody; Anti-MCH5 Antibody

Image / Experimental Information

Image 1 DescriptionAnti-CASP8 rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurakt Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:55 kDa Observed band size:55 kDa
Image 1 Alt TextHuman CASP8/ALPS2B Western blot (WB) 38144
Image 1 URLSource image
Image 2 DescriptionAnti-CASP8 rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurakt Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:55 kDa Observed band size:55 kDa
Image 2 Alt TextHuman CASP8/ALPS2B Immunohistochemistry(IHC) 38145
Image 2 URLSource image
Image 3 DescriptionAnti-CASP8 rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurakt Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:55 kDa Observed band size:55 kDa
Image 3 Alt TextHuman CASP8/ALPS2B Immunofluorescence(IF) 38146
Image 3 URLSource image
Image 4 DescriptionAnti-CASP8 rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurakt Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:55 kDa Observed band size:55 kDa
Image 4 Alt TextHuman CASP8/ALPS2B Immunoprecipitation(IP) 38147
Image 4 URLSource image

Background Information

Full Namecaspase 8, apoptosis-related cysteine peptidase
DescriptionCaspase 8 is a cysteine dependent endoprotease that plays a key role in the regulation of apoptosis (also referred as programmed cell death), an event which is known to be essential in growth and development of embryo, and maintenance of tissue homeostasis. Caspases are broadly classified as apoptosis or inflammation regulatory caspases based on their role in respective processes. Of those known, caspase - 3, -6, -7, -8 and -9 are categorized as apoptotic caspases, whereas caspase -1, -4, -5 and -12 are grouped as inflammatory caspases. The apoptotic caspases are further classified into initiator caspases (caspase -8 and -9) and effecter caspases (caspase -3, -6 and -7) based on their role in transducing the apoptotic signals emanating at the cell membrane.
Research Areas
  • Tumor Suppressors
Related Pathways
  • Death Receptor Signaling
  • EGFR Signaling Pathway
  • p53 Pathway
  • TNF Signaling
  • IL17 signaling pathway
Tags
  • Cancer Immunotherapy
  • Immune Checkpoint
  • Immunotherapy
  • Targeted Therapy
References
  1. Menon U, Raghuram P H, Kannan K, et al. Mutation Analysis of the Dimer Forming Domain of the Caspase 8 Gene in Oral Submucous Fibrosis and Squamous Cell Carcinomas[J]. Asian Pacific journal of cancer prevention: APJCP, 2014, 16(11): 4589-4592.

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