Anti-Caspase-9 Antibody, Rabbit Polyclonal sinobiological 310197-T44
$243.00
In stock
SKU
310197-T44
| Catalog No. | Size | Price (USD) |
| 310197-T44-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-Caspase-9 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), IHC-P (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Caspase-9 |
| Immunogen | E. coli-derived Human Caspase-9 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Caspase-9 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-APAF-3 Antibody; Anti-APAF3 Antibody; Anti-ICE-LAP6 Antibody; Anti-MCH6 Antibody; Anti-PPP1R56 Antibody
Image / Experimental Information
| Image 1 Description | Anti-CASP9 rabbit polyclonal antibody at 1:500 dilution Lane A: Hela Whole Cell Lysate Lane B: Hela(1um Staurosporine treatment for 3h) Whole Cell Lysate Lane C: Jurkat Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:46 kDa Observed band size:46 kDa |
| Image 1 Alt Text | Human Caspase-9 Western blot (WB) 38262 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-CASP9 rabbit polyclonal antibody at 1:500 dilution Lane A: Hela Whole Cell Lysate Lane B: Hela(1um Staurosporine treatment for 3h) Whole Cell Lysate Lane C: Jurkat Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:46 kDa Observed band size:46 kDa |
| Image 2 Alt Text | Human Caspase-9 Immunohistochemistry(IHC) 38263 |
| Image 2 URL | Source image |
| Image 3 Description | Anti-CASP9 rabbit polyclonal antibody at 1:500 dilution Lane A: Hela Whole Cell Lysate Lane B: Hela(1um Staurosporine treatment for 3h) Whole Cell Lysate Lane C: Jurkat Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:46 kDa Observed band size:46 kDa |
| Image 3 Alt Text | Human Caspase-9 Immunoprecipitation(IP) 38264 |
| Image 3 URL | Source image |
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Background Information
| Full Name | caspase 9, apoptosis-related cysteine peptidase |
| Description | Neural tube defects (NTDs) are birth defects of the nervous system and are the second most frequent cause of birth defects worldwide. The etiology of NTDs is complicated and involves both genetic and environmental factors. CASP9 is an initiator caspase in the intrinsic apoptosis pathway, which in Casp9-/- mice has been shown to result in NTDs because of decreased apoptosis. HSP90 inhibitors are identified here as a pharmacological approach for targeting autophagy via destabilization of ATG7, while an induced expression of CASP9, but not its apoptotic activity, is identified as a resistance mechanism to the cellular stress brought about by HSP90 inhibition. |
| Related Pathways |
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