| Catalog No. | Size | Price (USD) |
| 50649-T16-50 | 50 µL | $147.96 |
| 50649-T16-100 | 100 µL | $251.64 |
| 50649-T16-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CASPR2 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse CASPR2 |
| Immunogen | Recombinant Mouse CASPR2 / CNTNAP2 Protein (Catalog#50649-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse CASPR2 / CNTNAP2 (rM CASPR2 / CNTNAP2; Catalog#50649-M08H; NP_001004357.2; Met1-Ser1262). CASPR2 / CNTNAP2 specific IgG was purified by Mouse CASPR2 / CNTNAP2 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-5430425M22Rik Antibody; Anti-Caspr2 Antibody; Anti-Cntnap2 Antibody; Anti-Kiaa0868 Antibody; Anti-mKIAA0868 Antibody
Background Information
| Full Name | contactin associated protein-like 2 |
| Description | CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This protein encoding gene is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. CNTNAP2/CASPR2 may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. CNTNAP2/CASPR2 Seems to demarcate the juxtaparanodal region of the axo-glial junction. |
| References |
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