| Catalog No. | Size | Price (USD) |
| 200991-T08-50 | 50 µL | $147.96 |
| 200991-T08-100 | 100 µL | $251.64 |
| 200991-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-LAIR1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human LAIR1 |
| Immunogen | E. coli-derived Human LAIR1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human LAIR1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD305 Antibody; Anti-LAIR-1 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human LAIR1 in human lung with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human LAIR1 Immunohistochemistry(IHC) 24241 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human LAIR1 in human lung with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human LAIR1 Immunohistochemistry(IHC) 24242 |
| Image 2 URL | Source image |
Background Information
| Full Name | leukocyte-associated immunoglobulin-like receptor 1 |
| Description | Leukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. |
| Research Areas |
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| References |
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