Anti-LARS2 Antibody, Rabbit Polyclonal sinobiological 202210-T08

$143.00
In stock
SKU
202210-T08
Catalog No.SizePrice (USD)
202210-T08-5050 µL$147.96
202210-T08-100100 µL$251.64
202210-T08-200200 µL$355.32

General Information

Product nameAnti-LARS2 Antibody, Rabbit Polyclonal
Validated applicationsIHC-P (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman LARS2
ImmunogenE. coli-derived Human LARS2 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human LARS2 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-HLASA Antibody; Anti-KIAA0028 Antibody; Anti-LEURS Antibody; Anti-MGC26121 Antibody; Anti-mtLeuRS Antibody; Anti-PRLTS4 Antibody

Image / Experimental Information

Image 1 DescriptionImmunochemical staining of human LARS2 in human rectum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Image 1 Alt TextHuman LARS2 Immunohistochemistry(IHC) 22707
Image 1 URLSource image
Image 2 DescriptionImmunochemical staining of human LARS2 in human rectum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Image 2 Alt TextHuman LARS2 Immunohistochemistry(IHC) 22708
Image 2 URLSource image

Background Information

DescriptionLARS2 is located in the chromosome 3 common eliminated region-1 (C3CER1) at 3p21.3 and encodes mitochondrial leucyl-tRNA synthetase (mtLeuRS), a 903 amino acid protein. This enzyme is important in the production (synthesis) of proteins in cellular structures called mitochondria, the energy-producing centers in cells. Aminoacyl-tRNA synthetases then attach specific amino acids to the 3- ends of their cognate tRNAs, which is required in the cytoplasm and mitochondria for the translation of nuclear and mitochondrial encoded genes, respectively. Apart from two aminoacyl transfer RNA synthases, glycyl-tRNA synthetase and lysyl-tRNA synthetase, all other synthetases are encoded by separate genes for nuclear and mitochondrial functions.
References
  1. Riley LG, et al. (2016) Lars2 variants associated with hydrops, lactic acidosis, sideroblastic anemia, and multisystem failure. JIMD Rep 28 49-57.

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