| Catalog No. | Size | Price (USD) |
| 50015-T24-50 | 50 µL | $147.96 |
| 50015-T24-100 | 100 µL | $251.64 |
| 50015-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Cathepsin L Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse Cathepsin L |
| Immunogen | Recombinant Mouse Cathepsin L/CTSL Protein (Catalog#50015-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse Cathepsin L/CTSL (rM Cathepsin L/CTSL; Catalog#50015-M08H; P06797; Met1-Asn334). Cathepsin L/CTSL specific IgG was purified by Mouse Cathepsin L/CTSL affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-1190035F06Rik Antibody; Anti-CatL Antibody; Anti-Ctsl Antibody; Anti-Ctsl1 Antibody; Anti-fs Antibody; Anti-MEP Antibody; Anti-nkt Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of mouse CTSL in mouse kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Mouse Cathepsin L Immunohistochemistry(IHC) 23921 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of mouse CTSL in mouse kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Mouse Cathepsin L Immunohistochemistry(IHC) 23922 |
| Image 2 URL | Source image |
Background Information
| Full Name | cathepsin L |
| Description | Cathepsin L is a lysosomal cysteine protease that plays a major role in intracellular protein catabolism, and is potent in degrading collagen, laminin, elastin, as well as alpha-1 protease inhibitor and other structural proteins of basement membranes. It is secreted by liver flukes at all stages of their development in the mammalian host, are believed to play important roles in facilitating parasite migration (tissue degradation), feeding and immuno-evasion. Like many proteases, Cathepsin L is synthesized as an inactive preproenzyme, and cleavage of the 96-residue proregion is necessary to generate the fully active 221-residue mature enzyme. Studies have demonstrated that cleavage of the proregion occur autocatalytically under acidic conditions. The enzyme takes part in nutrient acquisition by catabolizing host proteins to absorbable peptides, facilitates the migration of the parasite through the host intestine and liver by cleaving interstitial matrix proteins such as fibronectin, laminin and native collagen and is implicated in the inactivation of host immune defenses by cleaving immunoglobulins. Recently, Cathepsin L has been shown to suppress Th1 immune response in infected laboratory animals making them susceptible to concurrent bacterial infections. Cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells, and induced by growth factors and tumor promoters. In addition to its role in protein degradation, evidence has accumulated for the participation of Cathepsin L in various physiological and pathological processes, such as tumor invasion and metastasis, bone resorption, spermatogenesis, and arthritis. Accordingly, Cathepsin L may prove useful as a diagnostic or prognostic marker of human tumor malignancy. |
| References |
|
title: HDL mimetics protect Alzheimer’s patients carrying APOE ε4 from SARS-CoV-2 invasion
authors: Ruodan Xu; Junwei Gao; ...; Mingdong Dong
journal: Nano Today
date: 2023-12-01
doi: 10.1016/j.nantod.2023.102051
cited_by_count: 3
techniques: Blocking Assay; Centrifugation; Control; Expressing; Imaging; Incubation; Membrane; SDS Page; Staining; Transfection; Western Blot
bioz_score: 93
title: A second functional furin site in the SARS-CoV-2 spike protein
authors: Yue Zhang; Li Zhang; ...; Youchun Wang
journal: Emerging microbes & infections
date: 2022-01-04
pmid: 34856891
doi: 10.1080/22221751.2021.2014284
pmcid: 8741242
cited_by_count: 35
techniques: Generated; Recombinant
bioz_score: 93
title: Cathepsin L expression in the carotid arteries of atherosclerotic swine
authors: Ayisha Zaka Bashir; Khalid Bashir; ...; Devendra K. Agrawal
journal: Archives of Medical Sciences. Atherosclerotic Diseases
date: 2019-12-02
pmid: 32373754
doi: 10.5114/amsad.2019.90153
pmcid: 7197027
cited_by_count: 2
techniques: Immunofluorescence; Immunohistochemistry; Incubation; Staining
bioz_score: 93
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